Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interleukin-6–dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer

11 May 2007

Abstract excerpt

Signal transducer and activator of transcription 3 (Stat3) is implicated in the pathogenesis of many malignancies and essential for IL-6-dependent survival and growth of multiple myeloma cells. Here, we demonstrate that the gene encoding oncogenic microRNA-21 (miR-21) is controlled by an upstream enhancer containing 2 Stat3 binding sites strictly conserved since the first observed evolutionary appearance of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circular RNAs in diseases
Share to Cytokine Signaling Pathways and Interactions
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17496199
DOI: 10.1182/blood-2007-03-081133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interleukin-6–dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancerPMID 17496199Read ↗

The role of IL-21 in hematological malignancies.Semantic proximity Read ↗

Master and servant: LINC00152 – a STAT3-induced long noncoding RNA regulates STAT3 in a positive feedback in human multiple myelomaSemantic proximity Read ↗

IFN Induces miR-21 through a Signal Transducer and Activator of Transcription 3–Dependent Pathway as a Suppressive Negative Feedback on IFN-Induced ApoptosisSemantic proximity Read ↗

Interplay between microRNAs and the STAT3 signaling pathway in human cancersSemantic proximity Read ↗

IL6R-STAT3-ADAR1 (P150) interplay promotes oncogenicity in multiple myeloma with 1q21 amplificationSemantic proximity Read ↗

Advances of the interleukin-21 signaling pathway in immunity and angiogenesisSemantic proximity Read ↗

Targeting the Interleukin-6/Jak/Stat Pathway in Human MalignanciesSemantic proximity Read ↗

Integrative analysis of differential miRNA and functional study of miR-21 by seed-targeting inhibition in multiple myeloma cells in response to berberineSemantic proximity Read ↗

Epstein-Barr virus infection induces miR-21 in terminally differentiated malignant B cellsSemantic proximity Read ↗

Interleukin-6-dependent gene expression profiles in multiple myeloma INA-6 cells reveal a Bcl-2 family-independent survival pathway closely associated with Stat3 activation.Semantic proximity Read ↗

More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancerSemantic proximity Read ↗

Pleiotropic anti-myeloma activity of ITF2357: inhibition of interleukin-6 receptor signaling and repression of miR-19a and miR-19bSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.