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Article

Dual role of IL-21 in megakaryopoiesis and platelet homeostasis.

Haematologica - 1 Apr 2017

Benbarche Salima, Strassel Catherine, Angénieux Catherine, Mallo Léa, Freund Monique, Gachet Christian, Lanza François, de la Salle Henri

Abstract excerpt

Gene profiling studies have indicated that in vitro differentiated human megakaryocytes express the receptor for IL-21 (IL-21R), an immunostimulatory cytokine associated with inflammatory disorders and currently under evaluation in cancer therapy. The aim of this study was to investigate whether IL-21 modulates megakaryopoiesis. We first checked the expression of IL-21 receptor on human bone marrow and in vitro...

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Identifiers

PMID: 28057742
DOI: 10.3324/haematol.2016.143958
PMCID: PMC5395104

Genes

STAT3
JAK3

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