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A let-7 microRNA-RALB axis links the immune properties of iPSC-derived megakaryocytes with platelet producibility

22 Mar 2024

Abstract excerpt

We recently achieved the first-in-human transfusion of induced pluripotent stem cell-derived platelets (iPSC-PLTs) as an alternative to standard transfusions, which are dependent on donors and therefore variable in supply. However, heterogeneity characterized by thrombopoiesis-biased or immune-biased megakaryocytes (MKs) continues to pose a bottleneck against the standardization of iPSC-PLT manufacturing. To...

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Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
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PMID: 38519457
DOI: 10.1038/s41467-024-46605-0

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