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Article

Functional expression of TRAIL and TRAIL-R2 during human megakaryocytic development.

Journal of cellular physiology - 1 Sept 2005

Melloni Elisabetta, Secchiero Paola, Celeghini Claudio, Campioni Diana, Grill Vittorio, Guidotti Lia, Zauli Giorgio

Abstract excerpt

The expression and function of surface TRAIL and TRAIL receptors were investigated in primary megakaryocytic cells, generated in serum-free liquid phase from peripheral human CD34(+) cells. The surface expression of both TRAIL and "death receptor" TRAIL-R2 became detectable starting from the early phase of megakaryocytic differentiation (day 6 of culture) and persisted at later (days10-14) culture times. On the...

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PMID: 15828026
DOI: 10.1002/jcp.20358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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