Article
c-FLIP protects eosinophils from TNF-α-mediated cell death in vivo.
PloS one - 1 Jan 2014
Gordy Claire, Liang Jie, Pua Heather, He You-Wen
Abstract excerpt
Understanding the signals that regulate eosinophil survival and death is critical to developing new treatments for asthma, atopy, and gastrointestinal disease. Previous studies suggest that TNF-α stimulation protects eosinophils from apoptosis, and this TNF-α-mediated protection is mediated by the upregulation of an unknown protein by NF-κB. Here, we show for the first time that eosinophils express the caspase...
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