Article
The causal role of smoking on the risk of hip or knee replacement due to primary osteoarthritis: a Mendelian randomisation analysis of the HUNT study.
Osteoarthritis and cartilage - 1 Jun 2017
Johnsen M B, Vie G Å, Winsvold B S, Bjørngaard J H, Åsvold B O, Gabrielsen M E, Pedersen L M, Hellevik A I, Langhammer A, Furnes O, Flugsrud G B, Skorpen F, Romundstad P R, Storheim K, Nordsletten L, Zwart J A
Abstract excerpt
OBJECTIVE: Smoking has been associated with a reduced risk of hip and knee osteoarthritis (OA) and subsequent joint replacement. The aim of the present study was to assess whether the observed association is likely to be causal. METHOD: 55,745 participants of a population-based cohort were genotyped for the rs1051730 C > T single-nucleotide polymorphism (SNP), a proxy for smoking quantity among smokers. A...
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