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Article

Body Mass Index Differentially Moderates Heritability of Total Joint Replacement Due to Hip and Knee Osteoarthritis: A Cohort Study of 29,893 Swedish Twin Pairs.

The Journal of bone and joint surgery. American volume - 21 Jul 2021

Hailer Nils P, Kuja-Halkola Ralf, Brüggemann Anders, Pedersen Nancy L, Michaëlsson Karl

Abstract excerpt

BACKGROUND: Osteoarthritis and obesity are diseases with high prevalence, and they share common etiologies. We investigated the sex-specific genetic susceptibility to hip and knee osteoarthritis necessitating total joint replacement (TJR), and how body mass index (BMI) moderated the heritability of these osteoarthritis phenotypes. METHODS: We linked 29,893 twin pairs with information on BMI in the Swedish Twin...

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PMID: 33844661
DOI: 10.2106/JBJS.20.00946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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