Genetic insights into the risk of hip osteoarthritis on stroke: A single-variable and multivariable Mendelian randomization.

doi:10.1371/journal.pone.0313032

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Article

Genetic insights into the risk of hip osteoarthritis on stroke: A single-variable and multivariable Mendelian randomization.

PloS one - 1 Jan 2025

Zhang Zhengze, Lian Yanan, He Yuewen, Liu Hao, Meng Kai, Wang Yong, Ma Wuhua

Abstract excerpt

BACKGROUND: Hip osteoarthritis has been identified as a potential risk factor for stroke, with previous studies have demonstrated an association between hip osteoarthritis and stroke. This study aims to further elucidate the causal relationship between the two, employing Two-Sample and Multivariable Mendelian randomization methods. METHODS: SNPs, derived from two extensive GWAS, served as instruments in exploring...

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Topics

Humans
Mendelian Randomization Analysis
Osteoarthritis, Hip
Risk Factors
Polymorphism, Single Nucleotide
Stroke

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genome-Wide Association Study

Genetic Predisposition to Disease

Diabetes Mellitus, Type 2

Male

C-Reactive Protein

Body Mass Index

Female

Source

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Identifiers

PMID: 39787159
DOI: 10.1371/journal.pone.0313032
PMCID: PMC11717317

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