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Article

Next-Generation Sequencing Reveals Pathway Activations and New Routes to Targeted Therapies in Cutaneous Metastatic Melanoma.

The American Journal of dermatopathology - 1 Jan 2017

Carlson J Andrew, Caldeira Xavier Jose Candido, Tarasen Ashley, Sheehan Christine E, Otto Geoff, Miller Vincent A, Stephens Philip J, Elvin Julia A, Vergilio Jo-Anne, Suh James, Gay Laurie M, Ross Jeffrey S

Abstract excerpt

BACKGROUND: Comprehensive genomic profiling of clinical samples by next-generation sequencing (NGS) can identify one or more therapy targets for the treatment of metastatic melanoma (MM) with a single diagnostic test. METHODS: NGS was performed on hybridization-captured, adaptor ligation-based libraries using DNA extracted from 4 formalin-fixed paraffin-embedded sections cut at 10 microns from 30 MM cases. The...

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Identifiers

PMID: 28045747
DOI: 10.1097/DAD.0000000000000729

Genes

BRAF
NRAS

Provenance

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