Article
Next-Generation Sequencing to Guide Treatment of Advanced Melanoma.
American journal of clinical dermatology - 1 Jun 2017
Griewank Klaus G, Schilling Bastian
Abstract excerpt
Next-generation sequencing (NGS) has provided significant insights into the pathogenesis of human malignancies. In advanced melanoma, two therapeutic avenues have appeared and have immediately become the standard of care, i.e. targeted therapy with small molecule inhibitors, and immune checkpoint blockade. Sequencing has always been essential for determining which patients may benefit from targeted therapies...
Topics
- High-Throughput Nucleotide Sequencing
- Humans
- Immunotherapy
- Melanoma
- Molecular Targeted Therapy
- Mutation
- Patient Selection
- Proto-Oncogene Proteins B-raf
- Skin Neoplasms