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Article

A Role for the Twins Protein Phosphatase (PP2A-B55) in the Maintenance of Drosophila Genome Integrity.

Genetics - 1 Mar 2017

Merigliano Chiara, Marzio Antonio, Renda Fioranna, Somma Maria Patrizia, Gatti Maurizio, Vernì Fiammetta

Abstract excerpt

The protein phosphatase 2A (PP2A) is a conserved heterotrimeric enzyme that regulates several cellular processes including the DNA damage response and mitosis. Consistent with these functions, PP2A is mutated in many types of cancer and acts as a tumor suppressor. In mammalian cells, PP2A inhibition results in DNA double strand breaks (DSBs) and chromosome aberrations (CABs). However, the mechanisms through which...

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Identifiers

PMID: 28040742
DOI: 10.1534/genetics.116.192781
PMCID: PMC5340330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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