Article
Mutagen sensitivity and suppression of position-effect variegation result from mutations in mus209, the Drosophila gene encoding PCNA.
The EMBO journal - 15 Mar 1994
Henderson D S, Banga S S, Grigliatti T A, Boyd J B
Abstract excerpt
The mus209B1 mutant of Drosophila melanogaster exhibits a complex pleiotropy of temperature-sensitive (ts) lethality, hypersensitivity to DNA-damaging agents such as ionizing radiation and methyl methanesulfonate, suppression of position-effect variegation (PEV), and female sterility. Our discove...
Topics
- Animals
- Base Sequence
- Chromosome Mapping
- Cloning, Molecular
- DNA
- DNA Repair
- Drosophila melanogaster
- Female
- Male
- Methyl Methanesulfonate
- Molecular Sequence Data
- Mutagens
- Mutation
- Nuclear Proteins
- Proliferating Cell Nuclear Antigen
- Radiation Tolerance
- Transcription, Genetic