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Article

Nuclear PP2A-Cdc55 prevents APC-Cdc20 activation during the spindle assembly checkpoint.

Journal of cell science - 1 Oct 2013

Rossio Valentina, Michimoto Takeshi, Sasaki Takeshi, Ohbayashi Iwai, Kikuchi Yoshiko, Yoshida Satoshi

Abstract excerpt

Cdc55, a regulatory B-subunit of protein phosphatase 2A (PP2A) complex, is essential for the spindle assembly checkpoint (SAC) in budding yeast, but the regulation and molecular targets of PP2A-Cdc55 have not been clearly defined or are controversial. Here, we show that an important target of Cdc55 in the SAC is the anaphase-promoting complex (APC) coupled with Cdc20 and that APC-Cdc20 is kept inactive by...

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PMID: 23886942
DOI: 10.1242/jcs.127365

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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