Article
A three-dimensional ParF meshwork assembles through the nucleoid to mediate plasmid segregation.
Nucleic acids research - 7 Apr 2017
McLeod Brett N, Allison-Gamble Gina E, Barge Madhuri T, Tonthat Nam K, Schumacher Maria A, Hayes Finbarr, Barillà Daniela
Abstract excerpt
Genome segregation is a fundamental step in the life cycle of every cell. Most bacteria rely on dedicated DNA partition proteins to actively segregate chromosomes and low copy-number plasmids. Here, by employing super resolution microscopy, we establish that the ParF DNA partition protein of the ParA family assembles into a three-dimensional meshwork that uses the nucleoid as a scaffold and periodically shuttles...
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