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Article

Uncoupling of nucleotide hydrolysis and polymerization in the ParA protein superfamily disrupts DNA segregation dynamics.

The Journal of biological chemistry - 14 Dec 2012

Dobruk-Serkowska Aneta, Caccamo Marisa, Rodríguez-Castañeda Fernando, Wu Meiyi, Bryce Kerstyn, Ng Irene, Schumacher Maria A, Barillà Daniela, Hayes Finbarr

Abstract excerpt

DNA segregation in bacteria is mediated most frequently by proteins of the ParA superfamily that transport DNA molecules attached via the segrosome nucleoprotein complex. Segregation is governed by a cycle of ATP-induced polymerization and subsequent depolymerization of the ParA factor. Here, we establish that hyperactive ATPase variants of the ParA homolog ParF display altered segrosome dynamics that block...

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Identifiers

PMID: 23093445
DOI: 10.1074/jbc.M112.410324
PMCID: PMC3522256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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