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Article

Bacterial DNA segregation by dynamic SopA polymers.

Proceedings of the National Academy of Sciences of the United States of America - 6 Dec 2005

Lim Grace E, Derman Alan I, Pogliano Joe

Abstract excerpt

Many bacterial plasmids and chromosomes rely on ParA ATPases for proper positioning within the cell and for efficient segregation to daughter cells. Here we demonstrate that the F-plasmid-partitioning protein SopA polymerizes into filaments in an ATP-dependent manner in vitro, and that the filaments elongate at a rate that is similar to that of plasmid separation in vivo. We show that SopA is a dynamic protein...

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Identifiers

PMID: 16306264
DOI: 10.1073/pnas.0507222102
PMCID: PMC1308903

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Bacterial DNA segregation by dynamic SopA polymers.PMID 16306264Read ↗

F plasmid partition depends on interaction of SopA with non-specific DNA.Semantic proximity Read ↗

Dynamic movement of the ParA-like Soj protein of B. subtilis and its dual role in nucleoid organization and developmental regulation.Semantic proximity Read ↗

A three-dimensional ParF meshwork assembles through the nucleoid to mediate plasmid segregation.Semantic proximity Read ↗

The F plasmid centromere, sopC, is required for full repression of the sopAB operon.Semantic proximity Read ↗

An SMC ATPase mutant disrupts chromosome segregation in Caulobacter.Semantic proximity Read ↗

Spo0J regulates the oligomeric state of Soj to trigger its switch from an activator to an inhibitor of DNA replication initiation.Semantic proximity Read ↗

Role of the ATP-binding site of SopA protein in partition of the F plasmid.Semantic proximity Read ↗

Caulobacter requires a dedicated mechanism to initiate chromosome segregation.Semantic proximity Read ↗

Soj (ParA) DNA binding is mediated by conserved arginines and is essential for plasmid segregation.Semantic proximity Read ↗

The chromosome partitioning proteins Soj (ParA) and Spo0J (ParB) contribute to accurate chromosome partitioning, separation of replicated sister origins, and regulation of replication initiation in Bacillus subtilis.Semantic proximity Read ↗

SMC condensation centers in Bacillus subtilis are dynamic structures.Semantic proximity Read ↗

Disruption of the F plasmid partition complex in vivo by partition protein SopA.Semantic proximity Read ↗

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