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Article

Friend or Foe: MicroRNAs in the p53 network.

Cancer letters - 10 Apr 2018

Luo Zhenghua, Cui Ri, Tili Esmerina, Croce Carlo

Abstract excerpt

The critical tumor suppressor gene TP53 is either lost or mutated in more than half of human cancers. As an important transcriptional regulator, p53 modulates the expression of many microRNAs. While wild-type p53 uses microRNAs to suppress cancer development, microRNAs that are activated by gain-of-function mutant p53 confer oncogenic properties. On the other hand, the expression of p53 is tightly controlled by a...

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Identifiers

PMID: 29330109
DOI: 10.1016/j.canlet.2018.01.013

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