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Article

Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain.

Human molecular genetics - 1 Feb 2017

Ottaviani Daniele, Marin Oriano, Arrigoni Giorgio, Franchin Cinzia, Vilardell Jordi, Sandre Michele, Li Wenwen, Parfitt David A, Pinna Lorenzo A, Cheetham Michael E, Ruzzene Maria

Abstract excerpt

HSJ1 (DNAJB2), a member of the DNAJ family of molecular chaperones, is a key player in neuronal proteostasis maintenance. It binds ubiquitylated proteins through its Ubiquitin Interacting Motifs (UIMs) and facilitates their delivery to the proteasome for degradation. Mutations in the DNAJB2 gene lead to inherited neuropathies such as Charcot-Marie-Tooth type-2, distal hereditary motor neuropathies, spinal...

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Source

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Identifiers

PMID: 28031292
DOI: 10.1093/hmg/ddw420
PMCID: PMC5409130

Genes

DNAJB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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