Article
The lysine-specific demethylase 1 is a novel substrate of protein kinase CK2.
Biochimica et biophysica acta - 1 Apr 2014
Costa Roberto, Arrigoni Giorgio, Cozza Giorgio, Lolli Graziano, Battistutta Roberto, Izpisua Belmonte Juan Carlos, Pinna Lorenzo A, Sarno Stefania
Abstract excerpt
Protein kinase CK2 is a pleiotropic serine/threonine kinase responsible for the generation of a substantial proportion of the human phosphoproteome. CK2 is generally found as a tetramer with two catalytic, α and α' and two non catalytic β subunits. CK2α C-terminal tail phosphorylation is regulated during the mitotic events and the absence of these phosphosites in α' suggests an isoform specialization. We used a...
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