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Mutations in melanocortin-4 receptor: From fish to men.

Progress in molecular biology and translational science - 1 Jan 2022

Tao Ya-Xiong

Abstract excerpt

Melanocortin-4 receptor (MC4R), expressed abundantly in the hypothalamus, is a critical regulator of energy homeostasis, including both food intake and energy expenditure. Shortly after the publication in 1997 of the Mc4r knockout phenotypes in mice, including increased food intake and severe obesity, the first mutations in MC4R were reported in humans in 1998. Studies in the subsequent two decades have...

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PMID: 35595350
DOI: 10.1016/bs.pmbts.2022.03.003

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