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Article

Impact of a Panel of 88 Single Nucleotide Polymorphisms on the Risk of Breast Cancer in High-Risk Women: Results From Two Randomized Tamoxifen Prevention Trials.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Mar 2017

Cuzick Jack, Brentnall Adam R, Segal Corrinne, Byers Helen, Reuter Caroline, Detre Simone, Lopez-Knowles Elena, Sestak Ivana, Howell Anthony, Powles Trevor J, Newman William G, Dowsett Mitchell

Abstract excerpt

Purpose At least 94 common single nucleotide polymorphisms (SNPs) are associated with breast cancer. The extent to which an SNP panel can refine risk in women who receive preventive therapy has not been directly assessed previously. Materials and Methods A risk score on the basis of 88 SNPs (SNP88) was investigated in a nested case-control study of women enrolled in the International Breast Intervention Study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 28029312
DOI: 10.1200/JCO.2016.69.8944
PMCID: PMC5455424

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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