Article
Assessment of the prognostic role of a 94-single nucleotide polymorphisms risk score in early breast cancer in the SIGNAL/PHARE prospective cohort: no correlation with clinico-pathological characteristics and outcomes.
Breast cancer research : BCR - 22 Aug 2017
Curtit Elsa, Pivot Xavier, Henriques Julie, Paget-Bailly Sophie, Fumoleau Pierre, Rios Maria, Bonnefoi Hervé, Bachelot Thomas, Soulié Patrick, Jouannaud Christelle, Bourgeois Hugues, Petit Thierry, Tennevet Isabelle, Assouline David, Mathieu Marie-Christine, Jacquin Jean-Philippe, Lavau-Denes Sandrine, Darut-Jouve Ariane, Ferrero Jean-Marc, Tarpin Carole, Lévy Christelle, Delecroix Valérie, Trillet-Lenoir Véronique, Cojocarasu Oana, Meunier Jérôme, Pierga Jean-Yves, Kerbrat Pierre, Faure-Mercier Céline, Blanché Hélène, Sahbatou Mourad, Boland Anne, Bacq Delphine, Besse Céline, Thomas Gilles, Deleuze Jean-François, Pauporté Iris, Romieu Gilles, Cox David G
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) have to date identified 94 genetic variants (single nucleotide polymorphisms (SNPs)) associated with risk of developing breast cancer. A score based on the combined effect of the 94 risk alleles can be calculated to measure the global risk of breast cancer. We aimed to test the hypothesis that the 94-SNP-based risk score is associated with clinico-pathological...
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