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Article

Breast cancer risk stratification in women of screening age: Incremental effects of adding mammographic density, polygenic risk, and a gene panel.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jul 2022

Evans D Gareth R, van Veen Elke M, Harkness Elaine F, Brentnall Adam R, Astley Susan M, Byers Helen, Woodward Emma R, Sampson Sarah, Southworth Jake, Howell Sacha J, Maxwell Anthony J, Newman William G, Cuzick Jack, Howell Anthony

Abstract excerpt

PURPOSE: There is great promise in breast cancer risk stratification to target screening and prevention. It is unclear whether adding gene panels to other risk tools improves breast cancer risk stratification and adds discriminatory benefit on a population basis. METHODS: In total, 10,025 of 57,902 women aged 46 to 73 years in the Predicting Risk of Cancer at Screening study provided DNA samples. A case-control...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35426792
DOI: 10.1016/j.gim.2022.03.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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