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Article

MORC family ATPases required for heterochromatin condensation and gene silencing.

Science (New York, N.Y.) - 15 Jun 2012

Moissiard Guillaume, Cokus Shawn J, Cary Joshua, Feng Suhua, Billi Allison C, Stroud Hume, Husmann Dylan, Zhan Ye, Lajoie Bryan R, McCord Rachel Patton, Hale Christopher J, Feng Wei, Michaels Scott D, Frand Alison R, Pellegrini Matteo, Dekker Job, Kim John K, Jacobsen Steven E

Abstract excerpt

Transposable elements (TEs) and DNA repeats are commonly targeted by DNA and histone methylation to achieve epigenetic gene silencing. We isolated mutations in two Arabidopsis genes, AtMORC1 and AtMORC6, which cause derepression of DNA-methylated genes and TEs but no losses of DNA or histone methylation. AtMORC1 and AtMORC6 are members of the conserved Microrchidia (MORC) adenosine triphosphatase (ATPase) family,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22555433
DOI: 10.1126/science.1221472
PMCID: PMC3376212

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