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Article

Nuclear factor erythroid 2-related factor 2 nuclear translocation induces myofibroblastic dedifferentiation in idiopathic pulmonary fibrosis.

Antioxidants & redox signaling - 1 Jan 2013

Artaud-Macari Elise, Goven Delphine, Brayer Stéphanie, Hamimi Akila, Besnard Valérie, Marchal-Somme Joëlle, Ali Zeina El, Crestani Bruno, Kerdine-Römer Saadia, Boutten Anne, Bonay Marcel

Abstract excerpt

AIMS: Oxidants have been implicated in the pathophysiology of idiopathic pulmonary fibrosis (IPF), especially in myofibroblastic differentiation. We aimed at testing the hypothesis that nuclear factor erythroid 2-related factor 2 (Nrf2), the main regulator of endogenous antioxidant enzymes, is involved in fibrogenesis via myofibroblastic differentiation. Fibroblasts were cultured from the lungs of eight controls...

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PMID: 22703534
DOI: 10.1089/ars.2011.4240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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