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Article

Activation of Nrf2 in fibroblasts promotes a skin aging phenotype via an Nrf2-miRNA-collagen axis.

Matrix biology : journal of the International Society for Matrix Biology - 1 Nov 2022

Hiebert Paul, Martyts Anastasiya, Schwestermann Jonas, Janke Katharina, Hafner Jürg, Boukamp Petra, Mazza Edoardo, Werner Sabine

Abstract excerpt

Aging is associated with progressive skin fragility and a tendency to tear, which can lead to severe clinical complications. The transcription factor NRF2 is a key regulator of the cellular antioxidant response, and pharmacological NRF2 activation is a promising strategy for the prevention of age-related diseases. Using a combination of molecular and cellular biology, histology, imaging and biomechanical studies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36367485
DOI: 10.1016/j.matbio.2022.09.002

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