Article
HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3.
Nature immunology - 1 Feb 2017
Gringhuis Sonja I, Hertoghs Nina, Kaptein Tanja M, Zijlstra-Willems Esther M, Sarrami-Forooshani Ramin, Sprokholt Joris K, van Teijlingen Nienke H, Kootstra Neeltje A, Booiman Thijs, van Dort Karel A, Ribeiro Carla M S, Drewniak Agata, Geijtenbeek Teunis B H
Abstract excerpt
The mechanisms by which human immunodeficiency virus 1 (HIV-1) avoids immune surveillance by dendritic cells (DCs), and thereby prevents protective adaptive immune responses, remain poorly understood. Here we showed that HIV-1 actively arrested antiviral immune responses by DCs, which contributed to efficient HIV-1 replication in infected individuals. We identified the RNA helicase DDX3 as an HIV-1 sensor that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.