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Article

Complement-Opsonized HIV-1 Overcomes Restriction in Dendritic Cells

29 Jun 2015

Abstract excerpt

DCs express intrinsic cellular defense mechanisms to specifically inhibit HIV-1 replication. Thus, DCs are productively infected only at very low levels with HIV-1, and this non-permissiveness of DCs is suggested to go along with viral evasion. We now illustrate that complement-opsonized HIV-1 (HIV-C) efficiently bypasses SAMHD1 restriction and productively infects DCs including BDCA-1 DCs. Efficient DC infection...

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PMID: 26121641
DOI: 10.1371/journal.ppat.1005005

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