Article
Analysis of blood methylation quantitative trait loci in East Asians reveals ancestry-specific impacts on complex traits.
Nature genetics - 1 May 2024
Peng Qianqian, Liu Xinxuan, Li Wenran, Jing Han, Li Jiarui, Gao Xingjian, Luo Qi, Breeze Charles E, Pan Siyu, Zheng Qiwen, Li Guochao, Qian Jiaqiang, Yuan Liyun, Yuan Na, You Chenglong, Du Siyuan, Zheng Yuanting, Yuan Ziyu, Tan Jingze, Jia Peilin, Wang Jiucun, Zhang Guoqing, Lu Xianping, Shi Leming, Guo Shicheng, Liu Yun, Ni Ting, Wen Bo, Zeng Changqing, Jin Li, Teschendorff Andrew E, Liu Fan, Wang Sijia
Abstract excerpt
Methylation quantitative trait loci (mQTLs) are essential for understanding the role of DNA methylation changes in genetic predisposition, yet they have not been fully characterized in East Asians (EAs). Here we identified mQTLs in whole blood from 3,523 Chinese individuals and replicated them in additional 1,858 Chinese individuals from two cohorts. Over 9% of mQTLs displayed specificity to EAs, facilitating the...
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