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A Targetable Fluorescent Sensor Reveals That Copper-Deficient <i>SCO1</i> and <i>SCO2</i> Patient Cells Prioritize Mitochondrial Copper Homeostasis

12 May 2011

Abstract excerpt

We present the design, synthesis, spectroscopy, and biological applications of Mitochondrial Coppersensor-1 (Mito-CS1), a new type of targetable fluorescent sensor for imaging exchangeable mitochondrial copper pools in living cells. Mito-CS1 is a bifunctional reporter that combines a Cu(+)-responsive fluorescent platform with a mitochondrial-targeting triphenylphosphonium moiety for localizing the probe to this...

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PMID: 21563821
DOI: 10.1021/ja2004158

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