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Cellular uptake and subcellular distribution of ruthenium-based metallodrugs under clinical investigation versus cisplatin

1 Jan 2011

Abstract excerpt

The cellular uptake and subcellular distribution including adduct formation with genomic DNA and uptake into mitochondria of two ruthenium(iii)-based drugs in clinical trials, KP1019 and NAMI-A, and cisplatin, was investigated in cisplatin sensitive and resistant A2780 human ovarian carcinoma cells. These data indicate that reduced metal uptake into mitochondria in combination with increased binding towards low...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21399784
DOI: 10.1039/c0mt00101e

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