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Potent anticancer activity of a novel iridium metallodrug via oncosis

6 Sept 2022

Abstract excerpt

Oncosis (from Greek ónkos, meaning "swelling") is a non-apoptotic cell death process related to energy depletion. In contrast to apoptosis, which is the main form of cell death induced by anticancer drugs, oncosis has been relatively less explored but holds potential to overcome drug resistance phenomena. In this study, we report a novel rationally designed mitochondria-targeted iridium(III) complex (OncoIr3)...

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PMID: 36066676
DOI: 10.1007/s00018-022-04526-5

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