Article
A gene variant of 11β-hydroxysteroid dehydrogenase type 1 is associated with obesity in children.
International journal of obesity (2005) - 1 Dec 2012
Olza J, Gil-Campos M, Leis R, Rupérez A I, Tojo R, Cañete R, Gil A, Aguilera C M
Abstract excerpt
BACKGROUND: The 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme catalyses the regeneration of active cortisol from inert cortisone and plays a critical role in tissue-specific corticosteroid reactions; therefore, 11β-HSD1 is a key molecule associated with the development of obesity. Despite evidence for its role in obesity, no genetic polymorphisms have been significantly associated with the disease per...
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