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Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function

15 Oct 2020

Abstract excerpt

The genetic mechanisms that determine the size of the adult pancreas are poorly understood. Imprinted genes, which are expressed in a parent-of-origin-specific manner, are known to have important roles in development, growth and metabolism. However, our knowledge regarding their roles in the control of pancreatic growth and function remains limited. Here we show that many imprinted genes are highly expressed in...

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PMID: 33057429
DOI: 10.1371/journal.pgen.1009069

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