Article
Association of DNA Mismatch Repair and Mutations in BRAF and KRAS With Survival After Recurrence in Stage III Colon Cancers : A Secondary Analysis of 2 Randomized Clinical Trials.
JAMA oncology - 1 Apr 2017
Sinicrope Frank A, Shi Qian, Allegra Carmen J, Smyrk Thomas C, Thibodeau Stephen N, Goldberg Richard M, Meyers Jeffrey P, Pogue-Geile Kay L, Yothers Greg, Sargent Daniel J, Alberts Steven R
Abstract excerpt
IMPORTANCE: The association of biomarkers with patient survival after recurrence (SAR) of cancer is poorly understood but may guide management and treatment. OBJECTIVE: To determine the association of DNA mismatch repair (MMR) status and somatic mutation in the B-Raf proto-oncogene (c.1799T>A [V600E]; BRAFV600E) or exon 2 of the KRAS proto-oncogene (KRAS) in the primary tumor with SAR in patients with stage III...
Topics
- Adenocarcinoma
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
- Bevacizumab
- Biomarkers, Tumor
- Cetuximab
- Colonic Neoplasms
- DNA Mismatch Repair