Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Model of the Interaction between the NF-κB Inhibitory Protein p100 and the E3 Ubiquitin Ligase β-TrCP based on NMR and Docking Experiments.

Journal of chemical information and modeling - 27 Feb 2017

Melikian Maxime, Eluard Baptiste, Bertho Gildas, Baud Véronique, Evrard-Todeschi Nathalie

Abstract excerpt

NF-κB is a major transcription factor whose activation is triggered through two main activation pathways: the canonical pathway involving disruption of IκB-α/NF-κB complexes and the alternative pathway whose activation relies on the inducible proteolysis of the inhibitory protein p100. One central step controlling p100 processing consists in the interaction of the E3 ubiquitin ligase β-TrCP with p100, thereby...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Magnetic Resonance Spectroscopy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Docking Simulation

Share to Molecular Dynamics Simulation

Share to Mutation

Share to Protein Binding

Share to Protein Conformation

Source

Identifiers

PMID: 28004927
DOI: 10.1021/acs.jcim.5b00409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Model of the Interaction between the NF-κB Inhibitory Protein p100 and the E3 Ubiquitin Ligase β-TrCP based on NMR and Docking Experiments.PMID 28004927Read ↗

Analysis of the RelA:CBP/p300 Interaction Reveals Its Involvement in NF-κB-Driven TranscriptionSemantic proximity Read ↗

Structural insights on the effects of mutation of a charged binding pocket residue on phosphopeptide binding to 14-3-3ζ protein.Semantic proximity Read ↗

Structural insights into the binding of the human receptor for advanced glycation end products (RAGE) by S100B, as revealed by an S100B-RAGE-derived peptide complex.Semantic proximity Read ↗

Unraveling the Allosteric Communication Mechanisms in T-Cell Receptor–Peptide-Loaded Major Histocompatibility Complex Dynamics Using Molecular Dynamics Simulations: An Approach Based on Dynamic Cross Correlation Maps and Residue Interaction Energy CalculationsSemantic proximity Read ↗

Decoding the deactivation mechanism of R192W mutation of ZAP-70 using molecular dynamics simulations and binding free energy calculations.Semantic proximity Read ↗

Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein–Protein InteractionsSemantic proximity Read ↗

Dynamical footprint of cross-reactivity in a human autoimmune T-cell receptorSemantic proximity Read ↗

Structure and Molecular Dynamics Simulations of Protein Tyrosine Phosphatase Non-Receptor 12 Provide Insights into the Catalytic Mechanism of the Enzyme.Semantic proximity Read ↗

Sequence dependence of C-end rule peptides in binding and activation of neuropilin-1 receptor.Semantic proximity Read ↗

The Trp triad within the V-domain of the receptor for advanced glycation end products modulates folding, stability and ligand binding.Semantic proximity Read ↗

Blocking the interaction between S100A9 and RAGE V domain using CHAPS molecule: A novel route to drug development against cell proliferation.Semantic proximity Read ↗

Flexible Linker Modulates Glycosaminoglycan Affinity of Decorin Binding Protein A.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.