Article
Flexible Linker Modulates Glycosaminoglycan Affinity of Decorin Binding Protein A.
Biochemistry - 18 Aug 2015
Morgan Ashli, Sepuru Krishna Mohan, Feng Wei, Rajarathnam Krishna, Wang Xu
Abstract excerpt
Decorin binding protein A (DBPA) is a glycosaminoglycan (GAG)-binding adhesin found on the surface of the bacterium Borrelia burgdorferi (B. burgdorferi), the causative agent of Lyme disease. DBPA facilitates bacterial adherence to extracellular matrices of human tissues and is crucial during the early stage of the infection process. Interestingly, DBPA from different strains (B31, N40, and PBr) show significant...
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