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Article

Analysis of CXCR5+Th17 cells in relation to disease activity and TNF inhibitor therapy in Rheumatoid Arthritis.

Scientific reports - 22 Dec 2016

Singh Deepika, Henkel Matthew, Sendon Bernadette, Feng June, Fabio Anthony, Metes Diana, Moreland Larry W, McGeachy Mandy J

Abstract excerpt

Th17 and TfH cells are thought to promote tissue inflammation and autoantibody production, respectively, in autoimmune diseases including rheumatoid arthritis (RA). TfH cells that co-express Th17 markers (CXCR5+Th17) encompass both of these pathogenic functions, and are increased in some human autoimmune settings including juvenile dermatomyositis. We investigated CXCR5+Th17 cells in RA subjects with stable or...

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Source

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Identifiers

PMID: 28004828
DOI: 10.1038/srep39474
PMCID: PMC5177940

Genes

CXCR5
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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