Article
Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells.
Arthritis research & therapy - 1 Jan 2006
Pharoah Daniel S, Varsani Hemlata, Tatham Richard W, Newton Katy R, de Jager Wilco, Prakken Berent J, Klein Nigel, Wedderburn Lucy R
Abstract excerpt
This study focuses upon three chemokines, namely CCL5, CXCL10 and CCL3, which are potential novel therapeutic targets in arthritis. The aim of the study was to analyse the expression and production of these three chemokines within the joints of children with juvenile idiopathic arthritis (JIA) of the oligoarticular and polyarticular subtypes. All three of these chemokines are highly expressed at the level of...
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