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Article

Enhancer DNA methylation in acute myeloid leukemia and myelodysplastic syndromes.

Cellular and molecular life sciences : CMLS - 1 Jun 2018

Benetatos Leonidas, Vartholomatos George

Abstract excerpt

DNA methylation (CpG methylation) exerts an important role in normal differentiation and proliferation of hematopoietic stem cells and their differentiated progeny, while it has also the ability to regulate myeloid versus lymphoid fate. Mutations of the epigenetic machinery are observed in hematological malignancies including acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) resulting in hyper- or...

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Share to Acute Myeloid Leukemia Research
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Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

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Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 29484447
DOI: 10.1007/s00018-018-2783-2
PMCID: PMC11105366

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