Article
Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes.
Epigenetics - 1 Aug 2014
Qu Ying, Lennartsson Andreas, Gaidzik Verena I, Deneberg Stefan, Karimi Mohsen, Bengtzén Sofia, Höglund Martin, Bullinger Lars, Döhner Konstanze, Lehmann Sören
Abstract excerpt
The extent and role of aberrant DNA methylation in promoter CpG islands (CGIs) have been extensively studied in leukemia and other malignancies. Still, CGIs represent only a small fraction of the methylome. We aimed to characterize genome-wide differential methylation of cytogenetically normal AML (CN-AML) cells compared with normal CD34(+) bone marrow cells using the Illumina 450K methylation array. Differential...
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