Article
A General Framework for the Evaluation of Genetic Association Studies Using Multiple Marginal Models.
Human heredity - 1 Jan 2016
Kitsche Andreas, Ritz Christian, Hothorn Ludwig A
Abstract excerpt
OBJECTIVE: In this study, we present a simultaneous inference procedure as a unified analysis framework for genetic association studies. METHODS: The method is based on the formulation of multiple marginal models that reflect different modes of inheritance. The basic advantage of this methodology is that no explicit formulation of the correlation between the test statistics is required. Moreover, the genotype...
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