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Article

Problems of glioblastoma multiforme drug resistance

1 Feb 2016

Abstract excerpt

Glioblastoma multiforme (GBL) is the most common and aggressive brain neoplasm. A standard therapeutic approach for GBL involves combination therapy consisting of surgery, radiotherapy, and chemotherapy. The latter is based on temozolomide (TMZ). However, even by applying such a radical treatment strategy, the mean patient survival time is only 14.6 months. Here we review the molecular mechanisms underlying the...

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PMID: 27260389
DOI: 10.1134/s0006297916020036

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