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Aldehyde dehydrogenase 1A1—a new mediator of resistance to temozolomide in glioblastoma

6 Nov 2012

Abstract excerpt

Implementation of chemotherapy with the drug temozolomide increased the overall survival of patients with glioblastoma multiforme (GBM; WHO grade IV), in particular when the O(6)-methylguanine DNA methyltransferase (MGMT) promoter is epigenetically silenced. Nevertheless, the prognosis remains poor, and relapse in GBM occurs regularly. This clinical behavior seems to be due to the existence of a therapy-resistant...

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PMID: 23132408
DOI: 10.1093/neuonc/nos270

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