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Article

Activated ERK1/2 increases CD44 in glomerular parietal epithelial cells leading to matrix expansion.

Kidney international - 1 Apr 2017

Roeder Sebastian S, Barnes Taylor J, Lee Jonathan S, Kato India, Eng Diana G, Kaverina Natalya V, Sunseri Maria W, Daniel Christoph, Amann Kerstin, Pippin Jeffrey W, Shankland Stuart J

Abstract excerpt

The glycoprotein CD44 is barely detected in normal mouse and human glomeruli, but is increased in glomerular parietal epithelial cells following podocyte injury in focal segmental glomerulosclerosis (FSGS). To determine the biological role and regulation of CD44 in these cells, we employed an in vivo and in vitro approach. Experimental FSGS was induced in CD44 knockout and wild-type mice with a cytotoxic podocyte...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27998643
DOI: 10.1016/j.kint.2016.10.015
PMCID: PMC5357449

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