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Article

Pathobiology of focal segmental glomerulosclerosis: new developments.

Current opinion in nephrology and hypertension - 1 May 2012

D'Agati Vivette D

Abstract excerpt

PURPOSE OF REVIEW: Focal segmental glomerulosclerosis (FSGS) is a major cause of nephrotic syndrome and renal failure. All forms of FSGS share podocyte injury and depletion as central mediators. This review focuses on new insights into pathogenesis from study of extrinsic toxins in experimental models, permeability factors in human disease, and novel genetic causes. RECENT FINDINGS: Experimental toxin models have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22357339
DOI: 10.1097/MNH.0b013e32835200df

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APOL1

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