Article
CD44 is required for the pathogenesis of experimental crescentic glomerulonephritis and collapsing focal segmental glomerulosclerosis.
Kidney international - 1 Mar 2018
Eymael Jennifer, Sharma Shagun, Loeven Markus A, Wetzels Jack F, Mooren Fieke, Florquin Sandrine, Deegens Jeroen K, Willemsen Brigith K, Sharma Vikram, van Kuppevelt Toin H, Bakker Marinka A, Ostendorf Tammo, Moeller Marcus J, Dijkman Henry B, Smeets Bart, van der Vlag Johan
Abstract excerpt
A key feature of glomerular diseases such as crescentic glomerulonephritis and focal segmental glomerulosclerosis is the activation, migration and proliferation of parietal epithelial cells. CD44-positive activated parietal epithelial cells have been identified in proliferative cellular lesions in glomerular disease. However, it remains unknown whether CD44-positive parietal epithelial cells contribute to the...
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