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Article

Anaplastic lymphoma kinase expression and gene alterations in glioblastoma: correlations with clinical outcome.

Journal of clinical pathology - 1 Jul 2017

Karagkounis George, Stranjalis George, Argyrakos Theodore, Pantelaion Varvara, Mastoris Konstantinos, Rontogianni Dimitra, Komaitis Spyridon, Kalamatianos Theodosis, Sakas Damianos, Tiniakos Dina

Abstract excerpt

AIMS: To study anaplastic lymphoma kinase (ALK) protein expression and possible underlying gene alterations in glioblastoma (GBM), correlating them with clinical outcome. METHODS: We studied ALK immunohistochemical expression and fluorescent in situ hybridisation (FISH)-detected ALK gene alterations in 51 GBMs (46 isocitrate dehydrogenase-1 (IDH1)R132H-negative and 5 IDH-mutant (IDH1R132H-positive)). We compared...

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Identifiers

PMID: 27993946
DOI: 10.1136/jclinpath-2016-204102

Genes

ALK
IDH1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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