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Article

Genomic Characterization of Dysplastic Nevi Unveils Implications for Diagnosis of Melanoma.

The Journal of investigative dermatology - 1 Apr 2017

Melamed Rachel D, Aydin Iraz T, Rajan Geena Susan, Phelps Robert, Silvers David N, Emmett Kevin J, Brunner Georg, Rabadan Raul, Celebi Julide Tok

Abstract excerpt

A well-defined risk factor and precursor for cutaneous melanoma is the dysplastic nevus. These benign tumors represent clonal hyperproliferation of melanocytes that are in a senescent-like state, but with occasional malignant transformation events. To portray the mutational repertoire of dysplastic nevi in patients with the dysplastic nevus syndrome and to determine the discriminatory profiles of melanocytic nevi...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27890785
DOI: 10.1016/j.jid.2016.11.017

Genes

PTEN
RAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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