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Article

Resetting the bar: Statistical significance in whole-genome sequencing-based association studies of global populations.

Genetic epidemiology - 1 Feb 2017

Pulit Sara L, de With Sera A J, de Bakker Paul I W

Abstract excerpt

Genome-wide association studies (GWAS) of common disease have been hugely successful in implicating loci that modify disease risk. The bulk of these associations have proven robust and reproducible, in part due to community adoption of statistical criteria for claiming significant genotype-phenotype associations. As the cost of sequencing continues to drop, assembling large samples in global populations is...

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PMID: 27990689
DOI: 10.1002/gepi.22032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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